Cart
sales@molnova.com
Home - Products - PI3K/Akt/mTOR signaling - mTOR - PP 242

PP 242

CAS No. 1092351-67-1

PP 242( PP242 | PP-242 )

Catalog No. M10346 CAS No. 1092351-67-1

A potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 47 In Stock
10MG 61 In Stock
25MG 87 In Stock
50MG 124 In Stock
100MG 215 In Stock
200MG 320 In Stock
500MG 530 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PP 242
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.
  • Description
    A potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively; shows no activity against PKC-β, RET, or JAK2 but inhibits PKC-α (IC50=50 nM); blocks the phosphorylation of Akt at S473 and prevents its full activation, inhibits proliferation of primary cells more completely than rapamycin.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PP242 | PP-242
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    DNA-PK|Hck|mTOR|p110δ|PDGFR|mTORC1|mTORC2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1092351-67-1
  • Formula Weight
    308.3378
  • Molecular Formula
    C16H16N6O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OC1=CC2=C(NC(C3=NN(C(C)C)C4=NC=NC(N)=C43)=C2)C=C1
  • Chemical Name
    1H-Indol-5-ol, 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Janes MR, et al. Nat Med. 2010 Feb;16(2):205-13. 2. Feldman ME, et al. PLoS Biol. 2009 Feb 10;7(2):e38. 3. Hoang B, et al. J Biol Chem. 2012 Jun 22;287(26):21796-805. 4. Hsieh AC, et al. Cancer Cell. 2010 Mar 16;17(3):249-61.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Autogramin-1

    Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.

  • mTOR inhibitor 9b

    mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 μM, respectively.

  • XL413 hydrochloride

    XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.

Sign In Join Free