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PP 242
CAS No. 1092351-67-1
PP 242( PP242 | PP-242 )
Catalog No. M10346 CAS No. 1092351-67-1
A potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
|
| 10MG | 61 | In Stock |
|
| 25MG | 87 | In Stock |
|
| 50MG | 124 | In Stock |
|
| 100MG | 215 | In Stock |
|
| 200MG | 320 | In Stock |
|
| 500MG | 530 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePP 242
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively.
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DescriptionA potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively; shows no activity against PKC-β, RET, or JAK2 but inhibits PKC-α (IC50=50 nM); blocks the phosphorylation of Akt at S473 and prevents its full activation, inhibits proliferation of primary cells more completely than rapamycin.
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In Vitro——
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In Vivo——
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SynonymsPP242 | PP-242
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptorDNA-PK|Hck|mTOR|p110δ|PDGFR|mTORC1|mTORC2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1092351-67-1
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Formula Weight308.3378
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Molecular FormulaC16H16N6O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC1=CC2=C(NC(C3=NN(C(C)C)C4=NC=NC(N)=C43)=C2)C=C1
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Chemical Name1H-Indol-5-ol, 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Janes MR, et al. Nat Med. 2010 Feb;16(2):205-13.
2. Feldman ME, et al. PLoS Biol. 2009 Feb 10;7(2):e38.
3. Hoang B, et al. J Biol Chem. 2012 Jun 22;287(26):21796-805.
4. Hsieh AC, et al. Cancer Cell. 2010 Mar 16;17(3):249-61.
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